Patricio I. Meneses

BS, SUNY Stony Brook, 1990
PhD, Weill-Cornell Medical College, 1999
Postdoc, Harvard Medical School
Senior Research Investigator, University of Pennsylvania School of Medicine, Dept. of Neurology, Microbiology, & Immunology
Assistant Professor, Rosalind Franklin University of Medicine and Science, Dept. of Microbiology and Immunology, 2006-2011

Infection associated cancers are increasing at an alarming rate. Human papillomavirus (HPV) infection is estimated to cause one-third of the 1.5 million cancers attributed to viruses. The HPV related cancers include cervical cancer, head and neck squamous carcinoma, and anal cancer. Our long-term goal is to understand the basic processes that are necessary to establish HPV infection. Understanding the process of initial viral entry and trafficking can result in novel approaches to decrease infection and lessen the burden of HPV related cancers.

Full publication record: Meneses, PI

Gene Expression and DNA Methylation in Human Papillomavirus Positive and Negative Head and Neck Squamous Cell Carcinomas. Head and Neck Pathology. Snežana Stanković, April Rich, Nicole V. Anayannis, Stephanie Cabarcas-Petroski, Laura Schramm, Patricio I. Meneses. Accepted 9/2022.

The Process of Filopodia Induction during HPV Infection. Viruses 14(6): 1150. Biondo, A. and P. I. Meneses (2022).

Human Papillomavirus Minor Capsid Protein L2 Mediates Intracellular Trafficking into and Passage beyond the Endoplasmic Reticulum. Microbiol Spectr: e0150522. Morante, A. V., D. D. Baboolal, X. Simon, E. C. Pan and P. I. Meneses (2022).

Cabarcas-Petroski, S., Meneses, P.I. & Schramm, L. A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma. BMC Cancer 20, 1093 (November 11, 2020). https://doi.org/10.1186/s12885- 020-07569-8.

Host cell transcriptome modification upon exogenous HPV16 L2 protein expression. Xinwei An, Patricio I. Meneses Oncotarget. 2017 Oct 12;8(53):90730-90747.

The role of DCT in HPV16 infection of HaCaTs. Pinar Aksoy, Patricio I. Meneses. PLOS One. 2017 Jan 17;12(1):e0170158.

HPV entry into cells. Pinar Aksoy, Elinor Gottschalk, Patricio I. Meneses. Mutation Research-Reviews in Mutation Research. Mutat Res Rev Mutat Res. 2017 Apr - Jun;772:13-22.

A Dual Role for the Nonreceptor Tyrosine Kinase Pyk2 during the Intracellular Trafficking of Human Papillomavirus 16. Elinor Y. Gottschalk, Patricio I. Meneses. J. Virol. September 2015 89:17 9103-9114; Accepted manuscript posted online 24 June 2015.

HPV16 infection of HaCaTs is dependent on β4 integrin, and α6 integrin processing. Pınar Aksoy, Cynthia Y. Abban, Elizabeth Kiyashka, Weitao Qiang, Patricio I. Meneses. Virology. Volume 449, 20 January 2014, Pages 45–52.

Intermediate heparan sulfate binding during HPV 16 infection in HaCaTs. Annandita Kumar, Taylor Jacob, Cynthia Y. Abban, Patricio I. Meneses. Am J Ther. 2014 Sep-Oct; 21(5): 331–342. (Accepted December 2013). March 11, 2014 (epub).

Dabydeen SA, Meneses PI. Smurf2 alters BPV1 trafficking and decreases infection. Arch. Virol. 2011 May; 156(5):827-38. Epub 2011 Feb 12.

Abban, C. Y., Meneses, PI. Usage of heparan sulfate, integrins, and FAK in HPV16 infection. Virology 2010, July 20;403(1):1-16.

Dabydeen, S. A., Meneses, PI The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection Virology Journal 2009, 6:109.

Laniosz, V., Dabydeen, S. A., Havens, M. A. & Meneses, P. I. (2009). Human Papillomavirus Type 16 Infection of Human Keratinocytes Requires Clathrin, Caveolin-1, and is Brefeldin A-Sensitive. J. Virol.,JVI.00576-09. Epub 2009, Jun 3rd.

H Young A, Gentzch M, Abban CY, Jia Y, Meneses PI, Bridges RJ, Bradbury NA. Dynasore inhibits removal of wild-type and F508 CFTR from the plasma membrane. Biochem J. 2009, Jul 15;421(3):377-85.

Holthusen KA, Gonzalez AM, Meneses PI “Guanine exchange factor Vav2: a novel potential target for the development of drugs effective in the prevention of papillomavirus infection and disease”. Am J Ther. 2009 Nov-Dec;16(6):496-507.

Laniosz V, Holthusen KA, Meneses PI. “Bovine papillomavirus type 1: from clathrin to caveolin.” J Virol. 2008 Jul;82(13):6288-98.

J Virol. 82:6288-98. Cynthia Y Abban, Neil A Bradbury, Patricio I. Meneses. HPV16 and BPV1 infection can be blocked by the dynamin inhibitor dynasore. American Journal of Therapeutics. 2008 Jul-Aug;15(4)304-311.