Ipsita Banerjee

Dr. Ipsita Banerjee

Professor
Biochemistry

Email: [email protected]
Office: JMH 612
Phone: 718-817-4445

  • 2019 National Council of Undergraduate Research - Chemistry Division's Outstanding Research Mentorship Awardee.
    2022 Outstanding Four-Year College and University Chemistry Teaching Award from the New York Section of the American Chemical Society.
    2023 E. Emmet Reid Award from the Middle Atlantic Region of the American Chemical Society, for outstanding teaching Chemistry.
    2023 Distinguished Scientist Award from the Westchester Chemical Society.
    2023 Distinguished Research Award in Science and Mathematics, Fordham University.

  • Specifically, my research group is working on building supramolecular assemblies as smart materials for a variety of biological and biomedical applications. Our goal is to create tailored cell-surface adhesive materials for potential applications in regenerative medicine and new targeted drug delivery systems particularly with respect to tumor targeting.

    Research Area I: Development of New Biomaterials for Tissue Engineering (TE)

    3D Cell Tissue Scaffold

    The extent of the body’s capacity to regenerate and repair tissues largely varies, and significantly reduces with age, illness and extent of injury. The central feature of TE involves the development of new biomaterials that can efficiently mimic the extracellular matrix components of cells, promote growth of new tissue, replace damaged tissue and stimulate the regenerative process. Ideally, the biomaterial should also be biodegradable and degrade at a comparable rate to the growth of new tissue. We have thus far developed biomimetic scaffolds for potential applications in cartilage, bone, skin and neural TE. Over the past couple of years, we have been working on the utilization of three-dimensional (3D) printing technologies for preparing our scaffolds. This technology further allows us to produce scaffolds with a high degree of complexity and precision, most importantly it allows us to fine tune detailed dimensions at the micron level. Shown to the left are scaffolds developed in our lab for cartilage tissue engineering.

    Research Area II: Biocomputational and Experimental Approaches for Targeting Tumor Cells

    Peptide Conjugate Docked to Neuropilin Receptor,

    We develop novel peptide based-conjugates for targeting specific receptors of tumor cells. The optimal conjugates are synthesized and their nanoscale properties and ability to target tumor cells are validated through laboratory synthesis and cellular interaction studies. The results obtained serve as a basis for creating new avenues toward the development of antitumor drug delivery nanoscale materials. The mechanism of targeting is also investigated. On the left, is shown a newly developed peptide conjugate docked to neuropilin receptor 1 (Mol. Divers.2022. https://doi.org/10.1007/s11030-021-10354-9).

  • Biochemistry I
    Biochemistry II
    Bionanotechnology in Medicine
    Advances in Bionanotechology (Tutorial)
    Examining Biomaterials for Cancer Therapeutics (Tutorial)
    Topics in Materials Science
    Organic Chemistry Laboratory (II)
    General Chemistry Laboratory (I and II)

    • M. A. Biggs A. Das, H. L. Hunt, B. G. Goncalves, S. A. Frantzesko, C. A. Phan, I. A. Banerjee* “Design and development of peptide drug conjugates to target 3D tumoroids”. Under Revision 2024.
    • A. Das H. L. Hunt, V. Mahabadi, M. A. Biggs, C. A. Phan, I. A. Banerjee* Targeting the EGFR receptor and its triple mutant with Iridoid-Peptide conjugates. Under Revision. 2024.
    • B. G. Goncalves C. A. Phan, M. A. Biggs, H. L. Hunt, I. A. Banerjee* “NanoSelect. 2024, 2400042, doi.org/10.1002/nano.202400042
    • M. I. Rico B. G. Goncalves, H. L. Hunt, I. A. Banerjee*, “Design and self-assembly of tri-terpene peptide conjugates and their interactions with EGFR and EGFR mutant receptors – An In Silico and In Vitro Study”. Int. J. Pept. Res. Ther. 2024, 30, 3. DOI. 10.1007/s10989-023-10583-6
    • M. E. Murray B. G. Goncalves, M. A. Biggs, S. A. Frantzesko C. G. Lebedenko, I. A. Banerjee* “In Silico and SPR Study<”. Appl. Biol. Chem. 2024, 67, 28.
    • B. G. Goncalves R. M. Heise, I. A. Banerjee* “Development of Self-Assembled Biomimetic Nanoscale Collagen-Like Peptide Based Scaffolds for Tissue Engineering – An In Silico and Laboratory Study”. Biomimetics (Invited Article) 8 (7), 2023. doi.org/10.3390/biomimetics8070548
    • H. L. Hunt B. G. Goncalves, M. A. Biggs, M. I. Rico, M.E. Murray, C. G. Lebedenko, I. A. Banerjee* “in silico and Laboratory Study”. Mol. Divers. 2023. DOI. 10.1007/s11030-023-10772-x
    • B. G. Goncalves, I. A. Banerjee* “A Computational and Laboratory Approach for the Investigation of Interactions of Peptide Conjugated Natural Terpenes with EpHA2 receptor”. J. Mol. Modeling. 2023 doi:10.1007/s00894-023-05596-3
    • E. J. Boder, B. G. Goncalves, C. G. Lebedenko, I. A. Banerjee* “Probing the Interactions of LRP-1 Ectodomain derived peptides with Fibrillar Tau Protein and its Impact on Cellular Internalization”. Appl. Sci. 13, 12124-12143, 2023 https://doi.org/10.3390/app13020853.
    • C. G. Lebedenko, M. E. Murray, B. G. Goncalves, D. S. Perez, D. J. Lambo, I. A. Banerjee*. Interactions of nanoscale self-assembled peptide-based assemblies with glioblastoma cell models and spheroids. ACS Omega 8 (13), 12124-12143, 2023. doi.org/10.1021/acsomega.2c08049
    • L. R. Hart, C. G. Lebedenko, B. G. Goncalves, M. I. Rico, D. J. Lambo, D. S. Perez, I. A. Banerjee* “Exploration of Type II and III Collagen Binding Interactions with Short Peptide-Phenyl Pyrazole Conjugates via Docking, Molecular Dynamics and Laboratory Experiments”. Soft Mater. 21 (1), 53-82 2023 doi.org/10.1080/1539445X.2022.2147946.
    • S. M. Mitchell, R. M. Heise, M. E. Murray, D. J. Lambo, R. E. Daso, I. A. Banerjee* “An investigation of binding interactions of tumor-targeted peptide conjugated polyphenols with the kinase domain of Ephrin B4 and B2 receptors”. Mol. Divers. 2023. doi.org/10.1007/s11030-023-10621-x.
    • R. M. Heise, I. A. Banerjee* “Design of Short Peptides and Peptide Amphiphiles as Collagen Mimics and an investigation of their Interactions with Collagen using Molecular Dynamics Simulations and Docking Studies”. J. Mol. Modeling. 29 (19) 2022. doi.org/10.1007/s00894-022-05419-x
    • L. R. Hart, C. G. Lebedenko, S. M. Mitchell, R. E. Daso, I. A. Banerjee* In Silico Studies of Tumor Targeted Peptide-Conjugated Natural Products for Targeting Over-Expressed Receptors in Breast Cancer Cells using Molecular Docking, Molecular Dynamics and MMGBSA Calculations. Appl. Sci. 12 (1), 515; 2022. https://doi.org/10.3390/app12010515
    • D. J. Lambo, C. G. Lebedenko, P. A. McCallum, I. A. Banerjee* Molecular Dynamics, MMGBSA and Docking Studies of Natural Products Conjugated to Tumor Targeted-Peptide for Targeting BRAF V600E and MERTK Receptors. Mol. Divers.2022, https://doi.org/10.1007/s11030-022-10430-8
    • M. I. Rico, C. G. Lebedenko, S. M. Mitchell, I. A. Banerjee*, Molecular Dynamics Simulations, Docking and MMGBSA studies of Newly Designed Peptide Conjugated Glucosyloxy Stilbene Derivatives with Tumor Cell Receptors Mol. Divers.2022. https://doi.org/10.1007/s11030-021-10354-9
    • S. M. Mitchell, H. T. Pajovich, S. M. Broas, M. M. Hugo, I. A. Banerjee* Molecular Dynamics Simulations and in vitro Studies of Hybrid Decellularized Leaf-Peptide-Polypyrrole Composites for Potential Tissue Engineering Applications. J. Biomol. Struc. Dynamics. 1-16, 2022 doi: 10.1080/07391102.2021.2023643.
    • R. E. Daso, S. M. Mitchell, C. G. Lebedenko, R. M. Heise, I. A. Banerjee* “Exploring the Interactions of Ionic Liquids with Bioorganic Amphiphiles using computational approaches” ACS Omega, 6, 48, 32460–32474, 2021. https://doi.org/10.1021/acsomega.1c03864
    • C. G. Lebedenko, I. A. Banerjee* “Investigation of Self-Assembly of Symmetric and Asymmetric Peptide Bolaamphiphiles by COSMO-RS and Atomistic Simulations and their Interactions with POPC Bilayers”. Macromol. Theory Simul. 2100066, 2021 https://doi.org/10.1002/mats.202100066
    • M. M. Bashant, S. M. Mitchell, L. R. Hart, C. G. Lebedenko, I. A. Banerjee* “In Silico Studies of Interactions of Peptide Conjugated Cholesterol Metabolites and Betulinic acid with EGFR, LDR and N- terminal Fragment of CCKA Receptors”. J. Mol. Modeling 28 (1): 16, 2021 https://doi.org/10.1007/s00894-021-05007-5
    • E. J. Boder, I. A. Banerjee* Alzheimer’s Disease: Current Perspectives and Advances in Physiological Modeling, Bioengineering. 8 (12), 211, 2021. doi: 10.3390/bioengineering8120211.
    • C. G. Lebedenko, I. A. Banerjee* “Enhancing kidney vasculature in tissue engineering- current trends and approaches: A review”. Biomimetics, 6, 40, 2021. doi: 10.3390/biomimetics6020040
    • L. R. Hart, S. M. Mitchell, P. A. McCallum, R. E. Daso, I. A. Banerjee*, “Self-assembled peptide conjugated rosemary extract derivatives as drug delivery vehicles for targeting tumor cells”. Soft Materials. 2021. https://doi.org/10.1080/1539445X.2021.1926282.
    • S. M. Mitchell, R. M. Heise, D. J. Lambo, R. E. Daso, I. A. Banerjee* “Design, molecular docking and computational analysis of natural polyphenol-peptide conjugates for targeting EphB4 receptors”. J. Biomol. Struc. Dynamics. (Under Revision) 2021.
    • M. S. Whalen, R. E. Daso, M. F. Thomas, I. A. Banerjee* “Interactions of betainium and imidazolium based ionic liquids with peptide amphiphiles and their implications in the formation of nanohybrid composite gels”. J. Sol Gel Sci. Technol. 97, 488–504, 2021. doi. 10.1007/s10971-020-05434-5
    • S. M. Broas, I. A. Banerjee*, Design of Peptide-PEG-Thiazole bound Polypyrrole for Enhanced Neuronal Cell Interactions. Soft Materials. 19: 4, 428-443 2021. https://doi.org/10.1080/1539445X.2020.1853162
    • N. P. Wijedasa, R. E. Daso, S. M. Broas, I. A. Banerjee*, Varying Fish Scale Derived Hydroxyapatite bound Hybrid Peptide Nanofiber Scaffolds for Potential Applications in Periodontal Tissue Regeneration. Mater. Sci. Eng. C. 109, 110540, 2020.
    • R. E. Daso, I. A. Banerjee* Self‐Assembled Peptide‐Based Biocomposites for Near‐Infrared Light Triggered Drug Release to Tumor Cells”. Biotechnol. J. 15, e2000128, doi.org/10.1002/biot.202000128. 2020
    • R. E. Daso, L. J. Osborn, M. F. Thomas, I. A. Banerjee* Development of nanoscale hybrids from ionic liquid-peptide amphiphile assemblies as new functional materials. ACS Omega, 5, 14543-14554, 2020.
    • I. A. Banerjee*, K. R. Fath, S. H. Frayne, M. M. Hugo, B. Cohen “Development of Self-Assembled Phytosterol Based Nanoassemblies as Vehicles for Enhanced Uptake of Doxorubicin to HeLa Cells” Mater. Sci. Eng. C., 97, 451-460, 2019.

    Full List of Publications and Mentored Student Accomplishments